Objective: Musculoskeletal disorders include a spectrum from a self-resolving acute structure (such as strains) to chronic conditions with tendon and ligament failure. Although the role of mechanical loading has long been known in overuse injuries such as tendinopathy, mechanical loading also appears to be a possible trigger for several chronic inflammatory arthritis. Therefore, the goal of the study is to predict that the presence of high acute phase reactants may be considered as the onset of rheumatic disease in patients with subacromial impingement syndrome (SIS) who are unresponsive to conservative treatments.\nMaterial and Methods: 61 patients with a diagnosis of SIS were included in this study. All patients were treated by medications, subacromial corticosteroid injection, and physical therapy, respectively. The scores of visual analog scale (VAS) and the serum levels of ESR and CRP were collected before and after treatments from medical records.\nResults: The mean age of patients was 59.75±6.35 years. The mean duration of symptoms was 2.16±0.99 months. The pre- and post-treatment VAS scores were 8.15±0.63 and 8.11±0.82, respectively. The pre- and post-treatment the serum levels of ESR were 28.26±0.64 and 27.84±0.94, respectively. The pre- and post-treatment the serum levels of CRP were 0.61±0.40 and 0.60±0.36, respectively. There was no significant difference between pre- and post-treatments the values of VAS, ESR, and CRP (p>0.05).\nConclusion: The presence of high acute phase reactants in musculoskeletal disorders may lead clinicians to be careful about the development of rheumatic disease in the future.
Alloxan-induced hyperglycemia and oxidative stress are the major causes of chronic kidney damage (nephrotoxicity), which is characterized by highly distorted glomeruli and convoluted tubules. This research was planned for the study of the potential antioxidant role of the Arabic gum (AG) on alloxan-induced kidney cortex damage using physiological parameters, histopathological, and electron microscopic studies. Rats were equally categorized into four groups, 12 rats in each group as follows: untreated normal control rats (C), in the diabetic groups (D) a single dose of alloxan monohydrate (150 mg / kg body weight) has been injected to rats intraperitoneally, while the AG groups (G) and the diabetic + AG groups (D + G) received AG orally (25 mg/kg body weight/day) for 21 days. Alloxan injection significantly increased the urea, creatinine, and malondialdehyde (MDA) levels, but it significantly decreased the glutathione and catalase levels. Such alterations induced renal dysfunction, distorted glomeruli and convoluted tubules, the thickening of basement membrane, and distorted podocytes. Conversely, treatment with AG significantly decreased the urea, creatinine, and MDA levels, whereas it significantly increased the glutathione and catalase levels as compared to the diabetic groups. This was accompanied by an improvement in the kidney cortex tissues. Use AG as a natural agent according to the findings achieved in the current research, showed an antioxidant role and restored the kidney architecture, suppressed the oxidative stress damage, and improved the kidney function.
The study aimed to make comparison between sperm parameters assessment after preparation in IVF & ICSI and recording the best method one from the economic and healthy point of view for patient. A total of 100 couples which males with normozoospermia and oligozoospermia divided to 7 groups according to their motility (30%, 40%, 50%, 60%, 65%, 70%, 75%). The samples included in this study were splitting insemination cycles and the sibl oocytes were fertilized by IVF and ICSI with the same sperm sample. The fertilization rate, cleavage, quality of the embryo, and the rate of blastocyst formation were measured. The result revealed that the rate of fertilization was insignificantly differed between ICSI and IVF in cases of normospermia and oligospermia in all groups. The rates of embryo quality of cleavage and blastocyst stage were differing in ICSI and IVF. The proportion of blastocyst which transferred was increased significantly in IVF (68.8) compared to ICSI (56.1) depending on quality of blastocyst. In conclusion, ICSI in some cases couldn\'t improve fertilization, embryo quality and might make a negative effect on the process of extended culture to blastocyst stage. The choice between these methods depends on convenience, financial considerations.